Web1 Jul 2024 · Amgen and UCB have suffered another setback as they try to build momentum for Evenity, their new antibody therapy for osteoporosis. The EMA’s Committee for … WebRomosozumab blocks a protein called sclerostin. Sclerostin inhibits bone formation and mediates osteoclastic activity (the breakdown of old bone). However, blocking the synthesis of sclerostin actually increases bone formation, and to a lesser extent reduces bone resorption. 1. We know about the action of sclerostin because of a naturally ...
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