Cost of palifermin
Web2 rows · Kepivance (palifermin) is a member of the miscellaneous uncategorized agents drug class and is ... WebJul 1, 2007 · The estimated average total cost per patient for those treated with palifermin in the clinical trial was $73,938 (95% CI = $69,031-$78,845) versus $77,533 (95% CI = …
Cost of palifermin
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WebDec 7, 2024 · Chemotherapy. A second phase I study was undertaken in colorectal cancer patients treated with a 5-FU-based chemotherapy protocol. 27 This was a randomized (2:1) study of 81 patients who received palifermin (1, 10, 20, 40, 60 or 80 μg/kg/day) or placebo intravenously on days 4 to 8. Unlike the previous clinical study, dose-limiting toxicities … WebNov 29, 2024 · Palifermin exposure did not increase linearly with increasing doses. The first dose AUC0-inf (mean) of Kepivance 60 mcg/kg/day in adult patients (18 to 63 years) was 38.2 ng*hr/mL compared to 46.1 ng*hr/mL …
WebJan 31, 2024 · We compared the estimated total hospital costs (in 2005 United States dollars) incurred by patients who received palifermin in the clinical trial with those incurred by patients who received placebo. WebMay 19, 2024 · In these settings, the incidence of severe oral mucositis, defined as World Health Organization (WHO) grade 3 and 4 (G3/4), is reported at 80–100%, with a …
WebMar 1, 2013 · Hence, cost-effectiveness and the clinical benefits of palifermin among various conditioning regimens have also been debated. This article reviews the published literature on the efficacy of palifermin and makes evidence-based recommendations for the use of palifermin in the HSCT setting. WebPalifermin is a recombinant human keratinocyte growth factor that stimulates proliferation and differentiation of epithelial cells. Palifermin's biological activity exerts cytoprotective and healing effects that decrease cell injury caused by chemotherapy and radiation therapy. ... Hence, cost-effectiveness and the clinical benefits of ...
WebComment: Palifermin should not be administered within 24 hr before, during infusion of, or within 24 hr after administration of antineoplastic agents. Coadministration of palifermin …
WebMar 7, 2024 · According to Drugs.com, the cost of 3 units of palifermin intravenous powder for injection (6.25 mg) is $9,289.86. 3. According to the meta-analysis authors, … evsc frontlineWebNov 16, 2004 · Palifermin Reduces Estimated Downstream Costs of Autologous Stem Cell Transplant (SCT): Analysis of Phase 3 Trial Results. evsc hall of fame 2023WebNov 22, 2024 · Thus, for a 75-kg patient receiving eight doses of palifermin 120 μg/kg, the cost of a full course of treatment is around $16,800. Using an NNT value of 7, the … bruce labounty nhWebJul 19, 2011 · You can see Amgen (the maker of denosumab, and palifermin) & Novartis glowering at each other across the aisle at the poster session of ASCO. Both suggest … bruce kyle judge lee countyWebPalifermin is a truncated human recombinant keratinocyte growth factor [1] produced in Escherichia coli. KGF stimulates the growth of cells that line the surface of the mouth and intestinal tract.[2] ... Palifermin costs approximately 5,000 euros per treatment for a 70 kg patient. Annual sales. The worldwide profits for years the 2008–2011 ... bruce k warren esqWebNov 29, 2024 · Palifermin exposure did not increase linearly with increasing doses. The first dose AUC0-inf (mean) of Kepivance 60 mcg/kg/day in adult patients (18 to 63 years) was … bruce kurlander attorney columbia mdWebMucositis is a significant driver of the health care cost by increasing emergency room visits, hospitalization, ... economic analysis based on this study demonstrated that the benefit of decreased mucositis may … bruce k wilson